Clinical Trials and Studies
Rush participates in clinical trials across a wide range of specialties, discovering breakthrough treatments for cancer, neurological disorders, heart disease and more.
A
Alzheimer’s Disease and Related Dementias
- A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients with Early Alzheimer's Disease (BenfoTeam)
- Effect of Weight Loss Diets on Brain Health and Cognitive Decline Study
- PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE)
- Rush Memory Clinic Data Repository
- Study Assessing Safety and Efficacy of Buntanetap in Participants With Early Alzheimer's Disease
- Study of the Impact of Lifestyle Modifications on Thinking and Brain Health
- The Chronic Grief Management Intervention Study
Autism Spectrum Disorders
- Argus MDS: Developing Digital Tools for Diagnosis & Treatment Monitoring
- Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome (PMS)
- RISE: Training and Implementation of Evidence-Based Intervention in the Part C Early Intervention System
- SPARK: Simons Foundation Powering Autism Research for Knowledge
B
Blood Disorders and Hematologic Cancers
- A Prospective, Observational Cohort Study of Participants at Risk for Chronic Graft-Versus-Host Disease in the United States (THRIVE)
- A Study for Patients with Large B-Cell Lymphoma Who have Completed Initial Therapy
- Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease Treatment Study
- Cold Agglutinin Disease Real World Evidence Registry
- Drug Treatment Study for Children with Hemophilia A
- Evaluation of Pediatric Palliative Inpatient Process
- Expanded Access Protocol (EAP) for Subjects Receiving Lisocabtagene Maraleucel
- Health Literacy and Numeracy in Adolescent Patients with Hemophilia A and B Study
- Hemophilia A or B Treatment Study
- Hemophilia A Treatment Study
- Luspatercept versus Placebo in Subjects with Myeloproliferative Neoplasm-Associated Myelofibrosis
- Mastocytosis Patient Registry
- Molecular and Clinical Biology of von Willebrand Disease Study
- National Registry of All Persons with Bleeding and Clotting Disorders
- Newly Diagnosed T-Lymphoblastic Leukemia and T-Lymphoblastic Lymphoma Treatment Study
- Public Health Surveillance for the Prevention of Complications of Bleeding and Clotting Disorders
- Study for Subjects with Multiple Myeloma
- Study of Biomarkers in Hemophilic Arthropathy
- Study of Hepatitis C Virus Outcomes After Treatment in Patients with Bleeding Disorders
- Study Treating Patients With High-Risk Smoldering Myeloma
- Subcutaneous Epcoritamab Plus Lenalidomide Compared With R-GemOx for Relapsed/Refractory DLBCL
- Treatment Option for Relapsed or Refractory Multiple Myeloma
- Treatment Study for Children with Hemophilia B
- Treatment Study for Newly Diagnosed High Risk B-Lymphoblastic Leukemia in Patients with Ph-like TKI Sensitive Mutations
- Treatment Study for Patients with Localized Central Nervous System Germ Cell Tumors
- Treatment Study for Patients with Newly Diagnosed B-Lymphoblastic Leukemia or B-Lineage Lymphoblastic Lymphoma
- Treatment Study for Pediatric Patients with Hemophilia A
- Treatment Study for Subjects with Severe Hemophilia A or B
- Treatment Study for Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia
Brain Tumors
- Meningioma Drug Treatment Study
- NRG-CC014: Comparing Radiation Therapy to Usual Care for Patients with High-Risk Bone Asymptomatic Metastases, PREEMPT Trial
- Observation or Radiation Therapy in Treating Patients with Newly Diagnosed Grade II Meningioma that has been Completely Removed by Surgery
- Randomized Phase II Trial of Anti-Lag-3 and Anti-PD-1 Blockade vs. SOC in Patients with Recurrent Glioblastoma
- Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease
- Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients with Cancer that has Spread to the Brain
Breast Cancer
- De-Escalation of Breast Radiation Trial (DEBRA)
- E-Mindfulness Approaches for Living After Breast Cancer (HEAL-ABC)
- ELEGANT/STML-ELA-0422 Study for Breast Cancer Patients
- Estrogen Receptor Status Study
- Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25 (OFSET)
- MK2870-010
- NSABP B-63/ASCENT-05/GS-US-595-6184
- NSABP B-64/ EXActDNA-003 Breast Cancer Clinical Validation Study
- NU 23B05 for Patients with ER-Positive/HER2-Negative Advanced or Metastatic Breast Cancer
- ReDiscover-2 / RLY-2608-102
- Scalp Cooling for Breast and Ovarian Cancer Patients
- Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
- Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer (SCARLET)
- Study of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer (TAILOR RT)
C
COVID-19
- A Study for Outpatients with COVID-19
- COVID-19 Outpatient Thrombosis Prevention Trial
- COVID-19 Treatment Study for Non-Hospitalized Participants
- COVID-19 Vaccine Questionnaire
- Moderate Versus High Dose Vitamin D for Prevention of COVID-19
- RECOVER AUTO
- Shift Worker’s Resiliency to COVID-19
- Study of High-Flow Nasal Cannula with Prone Position for COVID-19 Acute Respiratory Distress Syndrome
D
Digestive Disorders
- Act Fast Study for Patients with Colorectal Cancer or Colorectal Lesion
- Efavaleukin Alfa Treatment for People with Ulcerative Colitis
- Gastrojejunostomy in Gastric Outlet Obstruction
- Inflammatory Bowel Disease (IBD) Registry
- New Treatment Development for People with Crohn's Disease
- Pancreatic Cancer Screening Study
- Paradoxical Diarrhea Treatment Study
- PATENT-E Study for Chronic Benign Stricture
- Study of Eating Patterns and Alcohol Consumption in Patients with Advanced Tubular Adenoma
- The COSMID Study for Patients with Diverticulitis
E
Emergency Medicine
F
G
Gastrointestinal Cancers
- Act Fast Study for Patients with Colorectal Cancer or Colorectal Lesion
- Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
- EXtending outcomes for PAncreas cancer patients with Nominal oligometastatic Disease (EXPAND): A Randomized Phase III Trial
- Initial Feasibility Study to Treat Pancreatic Cancer With a Planar LDR Source
- Pancreatic Cancer Screening Study
- Refractory Small Bowel Adenocarcinoma Treatment Study
- Retrospective Chart Review of Patients with Fibrolamellar Carcinoma
- Study of Eating Patterns and Alcohol Consumption in Patients with Advanced Tubular Adenoma
Genitourinary Cancers
- Chemoradiotherapy Study for Patients with Localized Muscle Invasive Bladder Cancer
- EA8191: INDICATE
- NRG-GU014: Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial
- Prostate Cancer Study
- STRIKE
- Study of Standard Systemic Therapy in Treating Prostate Cancer
- The ICONIC Trial for Rare Genitourinary Cancers
- The PROBE Trial: Treatment Study for Metastatic Kidney Cancer
- Treating Participants With Metastatic Prostate Cancer
- Treating Patients With High Risk Prostate Cancer
- Treatment Study for Patients With Muscle-Invasive Bladder Cancer
- Treatment Study for Rare Genitourinary Cancers
Gynecologic Cancers
- A Single-Arm, Phase 2 Study of Neoadjuvant Carboplatin and Mirvetuximab Soravtansine in Subjects with FRα-Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer
- C5721005/GOG-3116 Ocular Assessments in Patients Treated With Tivdak® in Recurrent or Metastatic Cervical Cancer
- Non-Treatment Study for Patients with Ovarian Cancer
- Scalp Cooling for Breast and Ovarian Cancer Patients
- Study to Compare Two Surgical Procedures in Women With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
H
Head and Neck Cancer
- Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer
- HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer Treatment Study
- Testing Immunotherapy Versus Observation in Patients with HPV Throat Cancer
- The MCLA-158-CL02 Study for Patients with Head and Neck Cancer
- Treatment Study for Squamous Cell Carcinoma of the Head and Neck
Heart and Vascular Conditions
- A Hybrid Implementation-Effectiveness Trial of Nurse-Delivered PTSD Treatment in Primary Care
- AAD Cross Over Study
- AIM-VT Trial
- APOLLO Trial: Treatment of Mitral Regurgitation
- Apple Watch Versus Zio Patch
- BOLT: DVT Indigo Aspiration System
- Boomerang Stentless Deep Vein Arterialization for Preventing Major Amputation in Peripheral Arterial DIsease/CLTI
- Deep Vein Arterialization for Amputation Prevention in PAD Patients
- ELEGANCE: Real-World Treatment of Lesions in the Peripheral Vasculature
- ELITE-BTK
- HIS-CRT
- Left Vs Left
- MAGICAL ISR Clinical Trial for Treatment of Blocked Arteries
- NobleStitch PFO Closure/Repair
- Rhythm Evaluation for AntiCoagulaTion with Continuous Monitoring of Atrial Fibrillation (REACT-AF)
- SELUTION 4 BTK
- Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (REDUCE PAS)
- The RAPID-PE Study
- TRUST Study
K
L
Lung and Chest Tumors
- A Study of Ifinatamab Deruxtecan versus Treatment of Physician's Choice in Subjects with Relapsed Small Cell Lung Cancer (IDeate-Lung02)
- A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants with Idiopathic Pulmonary Fibrosis
- ALCHEMIST Chemo-IO Study: Treatment for Treatment for Non-Small Cell Lung Cancer
- An ALCHEMIST Treatment Trial: Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer
- Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
- Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
- Prolonged Air Leak (PAL) Autologous Blood Patch Intervention Trial
- Pulmonary and Critical Care Registry
- S1900G : Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)
- Study of First Line Treatment and Maintenance in Non-Small Cell Lung Cancer
- TETON Study: Inhalation Treatment for IPF
- The Lung Health Cohort Study
- Treatment Study for Common EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
M
Mental Health Disorders
- Brain Training: Computer Games for Improved Cognition
- Clinical Research Study for Adolescents with Schizophrenia
- Deep Brain Stimulation for Treatment-Resistant Depression
- Depression Treatment Study
- ON-DEQ Study: A Nationwide, Remote Study to Help Smokers Increase Their Readiness to Quit
- Racial Microaggressions Toward People of Color During Physical Therapy
- The RECOVER Study: Vagus Nerve Stimulation for People with Difficult-to-Treat Bipolar Depression
- The REKINDLE Study for Adjustment Disorder
- Treatment Optimization Trial (TOT) for PTSD
N
Neurological Disorders
- Cellular Autoimmune Mechanisms of Narcolepsy Study
- Human Cortical Visual Prosthesis in People with Blindness
- Meningioma Drug Treatment Study
- Observation or Radiation Therapy in Treating Patients with Newly Diagnosed Grade II Meningioma that has been Completely Removed by Surgery
- Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease
- Study of Inflammation in Progressive Multifocal Leukoencephalopathy
- The Rush Cancer Biorepository Resource
O
P
Pain Management
Parkinson's Disease and Other Movement Disorders
- A Study of AAV2-GDNF in Adults with Moderate Parkinson’s Disease (REGENERATE-PD)
- Chorea Associated with Huntington’s Disease Treatment Study
- DBS Awake vs. Asleep
- Deep Brain Stimulator Registry
- DLBC Consortium
- Fracture Prevention Study
- Gut-Brain Health
- Huntington's Disease Cohort Prospective Registry Study
- LRRK2 in Early Parkinson's Disease
- MDS-UPDRS
- Multiple System Atrophy (MSA) with Orthostatic Hypotension (CYPRESS 0197)
- New Treatment for Cervical Dystonia (CD)
- NIH Racial Disparities in Parkinson's Disease
- Non-Pharmacological Study of Exercise in Parkinson's Disease
- Parkinson's Disease Genetics in the African American Population
- Peer Mentor Support and Caregiver Education
- Reevaluating the MDS-UMSARS for Multiple System Atrophy (MSA)
- Treatment Study for Adults with Early Manifest Huntington Disease
Pediatric Cancers and Blood Disorders
- Childhood B-Lymphoblastic Leukemia Treatment Study
- Hepatoblastoma Treatment Study
- Newly Diagnosed Classical Hodgkin Lymphoma Treatment Study
- Retrospective Chart Review of Patients with Fibrolamellar Carcinoma
- Study of Transient Myeloproliferative Disorder in Children with Down Syndrome
- Treatment Study for Patients with Acute Myeloid Leukemia
- Treatment Study for Patients with Anaplastic Large Cell Lymphoma
- Treatment Study of Non-Metastatic Desmoplastic Medulloblastoma in Children
Pediatric Neurological Disorders
- Drug Treatment Study for Boys with Duchenne Muscular Dystrophy
- Duchenne Muscular Dystrophy Treatment Study
- Efficacy, Safety and Tolerability of RO5186582 in Adults and Adolescents with Down Syndrome
- Expressive Language Sampling as an Outcome Measure
- Extension Study of Ataluren Treatment for Nonsense Mutation Dystrophinopathy
- Fragile X Study: Premutation Carriers
- Nonsense Mutation Dystrophinopathy and Ataluren Treatment Study
- Treatment Study for Boys with Duchenne Syndrome
Plastic and Reconstructive Surgery
S
Spine and Back Disorders
- Degenerative Disc Disease Treatment Study
- Effects of Aerobic Exercise on Chronic Lower Back Pain Study
- FUSE Study
- Lumbar Degenerative Spondylolisthesis Treatment Study
- Registry for Prospective Radiographic and Clinical Evaluation of Surgical Treatment for Cervical Deformity
- Registry for the Management and Outcome of Metastatic Spine Tumors
- Spinal Deformity Outcomes Database Registry
- Stryker Adherus
Stroke and Cerebrovascular Disease
- A Hybrid Implementation-Effectiveness Trial of Nurse-Delivered PTSD Treatment in Primary Care
- A Phase 2 Trial of ALN-APP in Patients with Cerebral Amyloid Angiopathy (cAPPricorn-1)
- A Study of Milvexian in Participants after an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack (LIBREXIA-STROKE)
- Anticoagulation in ICH Survivors for Stroke Prevention and Recovery (ASPIRE)
- Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA)
- Spontaneous Intracerebral Hemorrhage and Diffusion Weighted Imaging
- Statins in Intracerebral Hemorrhage (SATURN)