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Treatment Study for Patients with Newly Diagnosed Stage III Non-Small Cell Lung Cancer

Clinical Trial Title: 
Phase II trial of concurrent, split course chemoradiation followed by durvalumab (MEDI4736) in poor risk and/or elderly patients with newly diagnosed stage III non-small cell lung cancer.
Clinical Trial Protocol ID: 
Clinical Trial Investigator Name: 
Gaurav Marwaha, MD
Clinical Trial Protocol Description: 

The purpose of this study is to assess the safety and efficacy of a combined course of chemotherapy and radiation (chemoradiation) followed by immunotherapy (durvalumab) for poor risk or elderly patients with locally advanced non-small cell lung cancer (NSCLC). Combined chemoradiation followed by durvalumab is standard of care/FDA approved for patients with an excellent performance status (i.e. very “fit” patients); some combination or sequencing of chemotherapy with radiation (NOT followed by immunotherapy) is standard for poor risk/elderly patients. However, the chemoradiation followed by durvalumab approach is novel/investigational in poor risk or elderly patients. The term “investigational” means that it has not been approved by the U.S. Food and Drug Administration (FDA) and must be tested to see if it is a safe and effective treatment method for the disease or condition being studied.

Clinical Trial Eligibility Criteria: 

In order to participate you must meet the following criteria:

  • Are 18 years of age or older.
  • Have histologically or cytologically confirmed non-small cell lung cancer.
  • Have been deemed medically inoperable.
  • Have a body weight >30kg.

This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. If you wish to inquire via email, please include the title of the study in your message.

Clinical Trial Area: 
Lung and Chest Tumors
Contact Email: 
Contact Phone: 
(312) CANCER-1
Contact Name: 
Rush Cancer Center Clinical Trials Office