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Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease

Clinical Trial Title: 
Anti-amyloid treatment in asymptomatic Alzheimer’s disease
Clinical Trial Protocol ID: 
Clinical Trial Investigator Name: 
Neelum Aggarwal, MD
Clinical Trial Protocol Description: 

The purpose of this three-year study is to test the hypothesis that solanezumab will slow the decline of perceived cognitive functions and performance of everyday activities, as compared with placebo, in persons with preclinical Alzheimer’s disease.

Subjects will receive intravenous infusions of blinded study treatment every four weeks. Subjects will undergo MRI and PET scans, and an optional LP, cognitive and physical function testing, ECGs and blood draws throughout the course of the study. Clinic visits every 12 weeks will be conducted.

At Rush University Medical Center we expect to recruit approximately 10 patients. The treatment will be assigned randomly.

Clinical Trial Eligibility Criteria: 

In order to participate you must meet the following criteria::

  • Be 65-85 years of age.
  • Have a reliable study partner.

You will be excluded from the study if any of the following criteria apply to you::

  • Have serious or unstable illnesses, or do not have good venous access.
  • Cannot undergo MRI, PET or lumbar puncture procedures.

This is a partial list of inclusion and exclusion criteria.

Clinical Trial Area: 
Alzheimer’s Disease and Related Dementias
Contact Phone: 
(312) 942-2312
Contact Name: 
Karoll Meza