Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

This phase III trial compares the addition of induction chemotherapy, with carboplatin, paclitaxel and pembrolizumab, to chemotherapy and radiation, with cisplatin and pembrolizumab followed by pembrolizumab maintenance for the treatment of patients with cervical cancer that has spread to nearby tissue or lymph nodes (locally advanced). Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of cancer cells. Adding induction chemotherapy to the usual treatment of chemotherapy and radiation followed by maintenance may be more effective in treating patients with high risk, locally advanced cervical cancer.

In order to participate you must meet the following criteria:

• Have cervical cancer that was just diagnosed.
  • The cancer must be one of these types: squamous, adenocarcinoma, or adenosquamous.
• Have cancer that has advanced but is still in the pelvis.
  • This means it has grown deeper or spread to nearby areas or lymph nodes, but not far away.
• Have not had treatment for this cancer yet.
  • This includes no prior surgery, radiation, chemotherapy, or immunotherapy for cervical cancer.
• Are 18 years of age or older and able to care for yourself.
  • You should be well enough to do most daily activities.
• Are not pregnant or breastfeeding.
• Are healthy enough for treatment.
  • This means your blood counts, kidneys, and liver are working well, and you do not have a serious infection or major illness.

This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. If you wish to inquire via email, please include the title of the study in your message.