Clinical Trial TitleInfluence of cooling duration on efficacy in cardiac arrest patients: A multicenter, randomized, adaptive clinical trial to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.
National Clinical Trial Number:NCT04217551
Clinical Trial Protocol Description:
A multicenter, randomized, adaptive allocation clinical trial to determine if increasing durations of induced hypothermia are associated with an increasing rate of good neurological outcomes and to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.
Clinical Trial Eligibility Criteria:
In order to participate you must meet the following criteria:
- Coma after resuscitation from out of hospital cardiac arrest.
- Cooled to <34 deg C with 240 minutes of cardiac arrest.
- Definitive temperature control applied.
- Are at least 18 years of age.
- Informed consent from LAR including intent to maintain life support for 96 hours.
- Enrollment within 6 hours of initiation of cooling.
You will be excluded from the study if any of the following criteria apply to you:
- Hemodynamic instability.
- Pre-existing neurological disability or condition that confounds outcome determination.
- Pre-existing terminal illness, unlikely to survive to outcome determination.
- Planned early withdrawal of life support.
- Presumed sepsis as etio.
This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. If you wish to inquire via email, please include the title of the study in your message.
Clinical Trial Investigator
Yanina Purim-Shem-Tov, MD, MS
RUSH University Medical Center
1620 W Harrison St
Chicago, IL 60612