Treatment Study of Non-Metastatic Desmoplastic Medulloblastoma in Children

Clinical Trial Title

A phase II study for the treatment of non-metastatic desmoplastic medulloblastoma in children less than 4 years of age.

Contact Information

Nitin Sane

Clinical Trial Protocol Description:

The ACNS 1221 study is a single arm multi institutional trial for newly diagnosed young children (0- <4 years of age at study enrollment) with nodular desmoplastic or medulloblastoma with extensive nodularity (MO ND/MBEN medulloblastoma). The primary objective is estimating the progression-free survival distribution associated with treatment as per HITSKK 2000 protocol without intraventricular methotrexate.

Clinical Trial Eligibility Criteria:

In order to participate you must meet the following criteria:

  • Are less than 48 months old (4 years of age) at time of definitive surgery.
  • Have been newly diagnosed and have a confirmed histologic diagnosis of nodular desmoplastic (NO) medulloblastoma or medulloblastoma with extensive nodularity (MBEN) from rapid central pathology screening review.

This is a partial list of eligibility requirements.

Study Details

Clinical Trial Investigator

Mary Lou Schmidt, MD

Contact Information

Nitin Sane

(312) 355-0741


RUSH University Medical Center

1620 W Harrison St
Chicago, IL 60612

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