Clinical Trial TitleSurgical management of post-traumatic migraines on maximal medicine therapy.
Clinical Trial Protocol Description:
The purpose of this study is to determine if there is any superiority of one of the two current standard-of-care surgical treatments for often debilitating post-traumatic occipital migraines. These procedures involve freeing up or removing one or more of the occipital nerves deemed to be the source of these headaches. This is a single institution study at Rush University Medical Center, and there will be 25 patients enrolled in each study arm. The two standard-of-care procedures will be assigned to the study population randomly.
Clinical Trial Eligibility Criteria:
In order to participate you must meet the following criteria:
- Have a history of sharp or blunt head or neck trauma or a concussion as an inciting event for occipital headaches.
- Have chronic headaches occurring in the occipital distribution (back of head) for over 1 year, as diagnosed by neurologist.
- Are between 18 and 65 years of age.
- Are male or female.
You will be excluded from the study if any of the following criteria apply to you:
- Have a headache of any etiology other than specified in the inclusion criteria.
- Have occipital referral of pain arising from the atlantoaxial or upper zygapophyseal joints or from tender trigger points in neck muscles or their insertions.
- Are a pregnant or breastfeeding.
- Have significant comorbidities including short life expectancy, malignancy, degenerative central nervous system diseases, infection, severe psychiatric disorders.
This is a partial list of inclusion and exclusion criteria.
Clinical Trial Investigator
RUSH University Medical Center
1620 W Harrison St
Chicago, IL 60612