Clinical Trial Title

HIS-BUNDLE Corrective Pacing in Heart Failure (HIS-CRT)

National Clinical Trial Number:


Contact Information

Samia Majid

Clinical Trial Protocol Description:

The objective of this study is to conduct a prospective evaluation of the effectiveness and the mechanisms contributing to the benefits of HIS-CRT compared to Biventricular CRT (BIV-CRT) in patients with Right Bundle Branch Block (RBBB).

Clinical Trial Eligibility Criteria:

In order to participate you must meet the following criteria:

  • Are 18 years of age or older.
  • Have optimal medical therapy for heart failure by current guidelines.
  • Have class IIa or IIb guideline-based indication for CRT-D implant in RBBB patients, including one of the following:
    • New York Heart Association (NYHA) class II HF symptoms, LVEF ≤ 30% and QRS≥ 50 ms (IIb)
    • NYHA class III-IVa HF, LVEF ≤ 35%, and QRS duration ≥ 150 ms (IIa)
    • NYHA class III-IVa HF, LVEF ≤ 35%, and QRS duration 120-149 ms (IIb) 

You will be excluded from the study if any of the following criteria apply to you:

  • Are unable to obtain imaging data from echocardiogram within 1 year prior to date of randomization. 
  • Have LBBB or IVCD ECG morphology.
  • Are unable or unwilling to follow study protocol.
  • Have less than 12 months life expectancy at consent.
  • Are pregnant or are planning a pregnancy during duration of the study.
  • Are on heart transplant list or likely to undergo heart transplant.

This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. If you wish to inquire via email, please include the title of the study in your message.

Study Details

Clinical Trial Investigator

Parikshit Sharma, MD

Contact Information

Samia Majid

Clinical Trial Location

RUSH University Medical Center


RUSH University Medical Center

1620 W Harrison St
Chicago, IL 60612

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