HIS-CRT

The objective of this study is to conduct a prospective evaluation of the effectiveness and the mechanisms contributing to the benefits of HIS-CRT compared to Biventricular CRT (BIV-CRT) in patients with Right Bundle Branch Block (RBBB).

In order to participate you must meet the following criteria:

• Are 18 years of age or older.
• Have optimal medical therapy for heart failure by current guidelines.
• Have class IIa or IIb guideline-based indication for CRT-D implant in RBBB patients, including one of the following:
  • New York Heart Association (NYHA) class II HF symptoms, LVEF ≤ 30% and QRS≥ 50 ms (IIb)
  • NYHA class III-IVa HF, LVEF ≤ 35%, and QRS duration ≥ 150 ms (IIa)
  • NYHA class III-IVa HF, LVEF ≤ 35%, and QRS duration 120-149 ms (IIb) 

You will be excluded from the study if any of the following criteria apply to you:

• Are unable to obtain imaging data from echocardiogram within 1 year prior to date of randomization. 
• Have LBBB or IVCD ECG morphology.
• Are unable or unwilling to follow study protocol.
• Have less than 12 months life expectancy at consent.
• Are pregnant or are planning a pregnancy during duration of the study.
• Are on heart transplant list or likely to undergo heart transplant.

This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. If you wish to inquire via email, please include the title of the study in your message.