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Chemotherapy — Clinical Trials

Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study

A randomized phase III study of mFOLFOX6/bevacizumab combination chemotherapy with or without atezolizumab or atezolizumab monotherapy in the first-line treatment of patients with deficient DNA mismatch repair (dMMR) metastatic colorectal cancer.

Glioblastoma Drug Treatment Study

A phase II/III randomized trial of veliparib or placebo In combination with adjuvant temozolomide In newly diagnosed glioblastoma with MGMT promoter hypermethylation.

HER2-Positive Locally Advanced/Metastatic Breast Cancer Treatment Study

A randomized, multicenter, open label study of MM-302 plus trastuzumab vs. chemotherapy of physician's choice plus trastuzumab in anthracycline naive patients with locally advanced/metastatic HER2-positive breast cancer.

Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Stage IV Non-Small Cell Lung Cancer Study

Maintenance systemic therapy versus local consolidative therapy (LCT) plus maintenance systemic therapy for limited metastatic non-small cell lung cancer (NSCLC): A randomized phase II/III trial.

Proton or Photon RT for Retroperitoneal Sarcomas Study

Phase I/II trial of pre-operative image guided intensity modulated proton radiation therapy (IMPT) or photon (IMRT) with simultaneously integrated boost to the high risk margin for retroperitoneal sarcomas.

Study Assessing the Accuracy of Tumor Biopsies After Chemotherapy

Assessing the accuracy of tumor biopsies after chemotherapy to determine if patients can avoid breast surgery.

Treatment Study for Patients with Prostate Cancer

Phase II-III trial of adjuvant radiotherapy following radical prostatectomy with or without adjuvant docetaxel.

Treatment Study for Patients with Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Metformin hydrochloride and combination chemotherapy in treating patients with stage III-IV ovarian, fallopian tube, or primary peritoneal cancer.