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Treatment Study for Patients With Soft Tissue Sarcoma

Clinical Trial Title: 
A phase Ib trial of neoadjuvant AMG 232 concurrent with preoperative radiotherapy in wild-type P53 soft tissue sarcoma (STS).
Clinical Trial Protocol ID: 
Clinical Trial Investigator Name: 
Dian Wang, MD, PhD
Clinical Trial Protocol Description: 

This phase Ib trial studies the side effects of MDM2 inhibitor AMG-232 and radiation therapy in treating patients with soft tissue sarcoma. MDM2 inhibitor AMG-232 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving MDM2 inhibitor AMG-232 and radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.

Clinical Trial Eligibility Criteria: 

In order to participate you must meet the following criteria:

  • Have pathologically proven diagnosis of grade 2-3 (intermediate or high grade) soft tissue sarcoma.
  • Have a planned definitive surgical resection of the primary tumor.
  • Have an Eastern Cooperative Oncology Group (ECOG) or Zubrod performance status of 0-1 within 30 days prior to registration.

This is a partial list of inclusion and exclusion criteria.

Clinical Trial Area: 
Contact Email: 
Contact Phone: 
(312) CANCER-1
Contact Name: 
Rush Cancer Center Clinical Trials Office