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Treatment Study for Patients with Ovarian Cancer

Clinical Trial Title: 
ATHENA: A multicenter, randomized, double-blind, placebo-controlled phase 3 study in ovarian cancer patients evaluating rucaparib and nivolumab as maintenance treatment following response to front-line platinum-based chemotherapy.
Clinical Trial Protocol ID: 
Clinical Trial Investigator Name: 
Lydia Usha, MD
Clinical Trial Protocol Description: 

This is a phase 3, randomized, multinational, double-blind, dual placebo-controlled, 4-arm study evaluating rucaparib and nivolumab as maintenance treatment following response to front-line treatment in newly diagnosed ovarian cancer patients. Response to treatment will be analyzed based on homologous recombination (HR) status of tumor samples.

Clinical Trial Eligibility Criteria: 

In order to participate you must meet the following criteria:

  • Have newly diagnosed advanced (FIGO stage III-IV) epithelial ovarian, fallopian tube, or primary peritoneal cancer.
  • Have completed cytoreductive surgery, including at least a bilateral salpingo-oophorectomy and partial omentectomy, either prior to chemotherapy (primary surgery) or following neoadjuvant chemotherapy (interval debulking).
  • Have completed first-line platinum-based chemotherapy and surgery with a response, in the opinion of the Investigator.
  • Have sufficient tumor tissue for planned analysis.

You will be excluded from the study if any of the following criteria apply to you:

  • Have pure sarcomas or borderline tumors or mucinous tumors.
  • Have active second malignancy.
  • Have known central nervous system brain metastases.
  • Have any prior treatment for ovarian cancer, other than the first-line platinum regimen.

This is a partial list of inclusion and exclusion criteria.

Clinical Trial Area: 
Gynecologic Cancers
Contact Phone: 
(312) 942-2417
Contact Name: 
Lois Winkelman