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Study of INFIELD Therapy for Head and Neck Cancer

Clinical Trial Title: 
INFIELD: A prospective phase II study of involved field elective volume de-intensification for oropharyngeal and laryngeal squamous cell carcinoma treated with intensity modulated radiation therapy.
Clinical Trial Protocol ID: 
Clinical Trial Investigator Name: 
Neilayan Sen, MD
Clinical Trial Protocol Description: 

This study aims to significantly improve the acute and late morbidity of patients with oropharyngeal and laryngeal squamous cell carcinoma both by tailoring the elective irradiation only to regions with a legitimate risk of recurrence (> 5%) and by lowering the elective dose to 40 Gy. Level IB will not be electively treated unless it is involved with pathologic or suspicious lymphadenopathy. Level V will not be treated unless two or more ipsilateral nodal levels are involved (or level V itself has pathologic or suspicious adenopathy). Levels III and IV will only be irradiated if the immediately proximal level contains pathologic lymphadenopathy (i.e. level III irradiated if level II is positive; level IV irradiated if level III is positive). We anticipate that this approach should dramatically improve the acute and late complication profile.

Clinical Trial Eligibility Criteria: 

In order to participate you must meet the following criteria:

  • Have pathologically-proven diagnosis of squamous cell carcinoma of the oropharynx or larynx. 
  • Have clinically or radiographically evident measureable disease at the primary site and/or nodal stations.
  • Have ECOG Performance Status 0-2.

This is a partial list of elgibility requirements.

Clinical Trial Area: 
Ear, Nose and Throat
Head and Neck Cancer
Contact Phone: 
(312) 942-5183
Contact Name: 
Steffi Leung