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Study Evaluating the Pregnancy Outcomes of Interrupting Endocrine Therapy for Women with Breast Cancer

Clinical Trial Title: 
A study evaluating the pregnancy outcomes and safety of interrupting endocrine therapy for women with breast cancer who desire pregnancy.
Clinical Trial Protocol ID: 
18082902
Clinical Trial Investigator Name: 
Ruta D. Rao, MD
Clinical Trial Protocol Description: 

The purpose of this study is to determine whether having a child after temporarily stopping endocrine treatment is feasible and safe in patients with a hormone receptor-positive early breast cancer. The study will look at whether a temporary interruption of endocrine therapy, with the goal of pregnancy and then resuming endocrine therapy to complete a standard course, is associated with a higher risk of breast cancer recurrence. The study will also assess the success of pregnancy, the health of the newborn, and the patient’s ability to breastfeed.

Clinical Trial Eligibility Criteria: 

In order to participate you must meet the following criteria:

  • Are between 18 and 42 years of age at enrollment.
  • Have received adjuvant endocrine therapy (SERM alone, GnRH analogue plus SERM or AI) for ≥18 months but ≤30 months for early breast cancer.
  • Wish to become pregnant.

You will be excluded from the study if any of the following criteria apply to you:

  • Are post-menopausal at breast cancer diagnosis.
  • Have current local, loco-regional relapse and/or distant metastatic breast cancer.
  • Have concurrent disease or condition that would make you inappropriate for study participation or any serious medical disorder that would interfere with your safety.

This is a partial list of inclusion and exclusion criteria.

Clinical Trial Area: 
Breast Cancer
Contact Phone: 
(312) 942-2993
Contact Name: 
Chelsea McPeek, RN