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Risk Factors for Women With Cerebral Aneurysm Study

Clinical Trial Title: 
Risk factors associated with cerebral aneurysm formation in women
Clinical Trial Protocol ID: 
Clinical Trial Investigator Name: 
Michael Chen, MD
Clinical Trial Protocol Description: 

Our study will focus on better understanding why women appear to be at higher risk for the development of cerebral aneurysms. A recent study that showed oral contraceptive use and hormone replacement therapy may be protective against aneurysmal subarachnoid hemorrhage suggests that the cyclical hormonal fluctuations associated with physiologic menses may contribute to cerebral vascular instability and ultimately cerebral aneurysm formation.

We aim here to 1) study if a history of hormonal therapy (as contraceptive therapy or hormone replacement therapy) alters the risk of developing intracranial aneurysms and 2) assess if hormonal therapy alters the odds of aneurysmal rupture in women.

Clinical Trial Eligibility Criteria: 

In order to participate you must meet the following criteria:

  • Are a woman.
  • Had prior brain vascular imaging, including CT angiography, MR angiography or conventional catheter angiography.
  • Are willing to answer a short telephone questionnaire about medical, gynecologic and hormonal history, including prior use of oral contraceptives and hormone replacement therapies.

This is a partial list of eligibility requirements. 

Clinical Trial Area: 
Stroke and Cerebrovascular Disease
Women's Health
Contact Phone: 
(312) 563-2817
Contact Name: 
Michael Chen, MD