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Parkinson's Disease, Cognitive Impairment and Structural MRI

Clinical Trial Title: 
Parkinson's disease, cognitive impairment and structural MRI
Clinical Trial Protocol ID: 
Clinical Trial Investigator Name: 
Jennifer Goldman, MD
Clinical Trial Protocol Description: 

We are currently studying thinking and memory (cognition) in Parkinson disease. We are recruiting participants with PD, some who have cognitive problems and others who do not.

The study involves a clinical evaluation and a scan of your brain with magnetic resonance imaging (MRI) at Rush University Medical Center.

Clinical Trial Eligibility Criteria: 

In order to participate you must meet the following criteria:

  • Have Idiopathic PD based on the UK PD Society Brain Bank criteria.
  • Are 60-90 years of age, male or female, any race.
  • Have the ability to complete assessments.
  • Have been on stable doses of medications for at least 2 weeks at the time of evaluation.
  • Can control motor features such as tremor and dyskinesias sufficiently to obtain MRI scans.

You will be excluded from the study if any of the following criteria apply to you:

  • Have atypical or secondary forms of parkinsonism.
  • Have contraindications to MRI such as cardiac pacemaker/defibrillator, surgical clips, ear implants, foreign metallic implants.
  • Have severe or unstable medical conditions.
  • Have severe or unstable depression.
  • Have severe dementia that precludes consent or ability to tolerate MRI scan and assessment.
  • Have had neurosurgical interventions for PD or other conditions.
  • Have a history of systemic, psychiatric or other neurological conditions including seizures that could cause cognitive impairment.
  • Have anticholinergic medications.

This is a partial list of eligibility requirements. 

Clinical Trial Area: 
Parkinson's Disease and Other Movement Disorders
Contact Phone: 
(312) 942-8007
Contact Name: 
Jennifer Goldman, MD