Parkinson's Disease, Cognitive Impairment and Structural MRI
We are currently studying thinking and memory (cognition) in Parkinson disease. We are recruiting participants with PD, some who have cognitive problems and others who do not.
The study involves a clinical evaluation and a scan of your brain with magnetic resonance imaging (MRI) at Rush University Medical Center.
In order to participate you must meet the following criteria:
- Have Idiopathic PD based on the UK PD Society Brain Bank criteria.
- Are 60-90 years of age, male or female, any race.
- Have the ability to complete assessments.
- Have been on stable doses of medications for at least 2 weeks at the time of evaluation.
- Can control motor features such as tremor and dyskinesias sufficiently to obtain MRI scans.
You will be excluded from the study if any of the following criteria apply to you:
- Have atypical or secondary forms of parkinsonism.
- Have contraindications to MRI such as cardiac pacemaker/defibrillator, surgical clips, ear implants, foreign metallic implants.
- Have severe or unstable medical conditions.
- Have severe or unstable depression.
- Have severe dementia that precludes consent or ability to tolerate MRI scan and assessment.
- Have had neurosurgical interventions for PD or other conditions.
- Have a history of systemic, psychiatric or other neurological conditions including seizures that could cause cognitive impairment.
- Have anticholinergic medications.
This is a partial list of eligibility requirements.