Osteoarthritis of the Knee or Hip Treatment Study
The purpose of this study is to determine if subcutaneous injections (injected below the skin) of an investigational drug, are effective in decreasing pain and inflammation for individuals with osteoarthritis of the knee or hip. You will be randomly assigned to one of 3 doses of study drug or placebo. Nationwide, 320 subjects will be recruited for this study. At Rush University Medical Center we expect to recruit approximately 10 subjects.
In order to participate you must meet the following criteria:
- Have a diagnosis of osteoarthritis of the hip or knee.
- Are currently taking one of three oral NSAIDs daily to treat your osteoarthritis pain: naproxen 440-1000mg/day, celecoxib 200mg/day, diclofenac 100-150mg/day, or meloxicam.
- Have tried other medications, like opioids, to reduce the pain from your osteoarthritis.
You will be excluded from the study if any of the following criteria apply to you:
- Have a BMI > 39 kg/m2.
- Have a history of other inflammatory diseases (rheumatoid arthritis, gout or pseudogout, lupus, fibromyalgia, etc.).
- Are unwilling or unable to undergo an X-ray and MRI.
- Have had significant trauma or surgery to a knee, hip, or shoulder within the previous year.
This is a partial list of inclusion and exclusion criteria.