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Genetic Testing in Guiding Treatment for Patients with Brain Metastases

Clinical Trial Title: 
A071701: Genomically-guided treatment trial in brain metastases.
Clinical Trial Protocol ID: 
19102303
Clinical Trial Investigator Name: 
Joo Yeon Nam, MD
Clinical Trial Protocol Description: 

This phase II trial studies how well genetic testing works in guiding treatment for patients with solid tumors that have spread to the brain. Several genes have been found to be altered or mutated in brain metastases such as NTRK, ROS1, CDK or PI3K. Medications that target these genes such as abemaciclib, GDC-0084, and entrectinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Genetic testing may help doctors tailor treatment for each mutation.

Clinical Trial Eligibility Criteria: 

In order to participate you must meet the following criteria:

  • Have histologically confirmed metastatic disease to the brain from any solid tumor.
  • Have measurable CNS disease (> 10mm).
  • Have presence of clinically actionable alteration in NTRK, ROS1, or CDK pathway or PI3K pathway in both a brain metastasis and extracranial site.
  • Have tissue available for biomarker testing (any brain metastasis tissue and extracranial site from any prior resection or biopsy).

This is a partial list of elgibility requirements. To inquire about your eligibility, please call the contact number provided. 

Clinical Trial Area: 
Brain Tumors
Contact Email: 
Contact Phone: 
(312) CANCER-1
Contact Name: 
Rush Cancer Center Clinical Trials Office