Cellular Autoimmune Mechanisms of Narcolepsy Study

The purpose of this study is to determine whether narcolepsy patients with cataplexy exhibit an autoimmune response against the peptide orexin, which is depleted in this condition. A blood sample of 30 mL (about 2 tablespoons) will be taken to measure the participant’s cellular immune response against orexin. Subjects will also be tested for a DQB1 allele that is strongly linked to narcolepsy with cataplexy.

In order to participate you must meet the following criteria:

• Are at least 6 years of age.

You will be excluded from the study if any of the following criteria apply to you:

• Have narcolepsy without cataplexy.
• Have a sleep disorder other than narcolepsy.

This is a partial list of inclusion and exclusion criteria.