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Aneurysmal Subarachnoid Hemorrhage Treatment Study

Clinical Trial Title: 
Clinical Trial Protocol ID: 
Clinical Trial Investigator Name: 
George A. Lopez, MD
Clinical Trial Protocol Description: 

The purpose of this study is to investigate the safety and clinical effect of a continuous low-dose intravenous heparin treatment in patients who have an aneurysmal subarachnoid hemorrhage. Nationwide, 88 patients will be recruited for this study. At Rush University, we expect to recruit 8 patients. Treatment will be assigned randomly between low-dose intravenous heparin and prophylactic subcutaneous heparin (standard of care).

Clinical Trial Eligibility Criteria: 

In order to participate you must meet the following criteria:

  • Are between the ages of 18 and 70 years old.
  • Have a ruptured saccular aneurysm confirmed by angiography and repaired by coiling.
  • Have GCS 13-15 without focal deficit after repair.
  • Have odified Fisher 3 only (minimal IVH allowed).

You will be excluded from the study if any of the following criteria apply to you:

  • Have clipping or intracranial stent placement.
  • Have anti-platelet or oral anticoagulation prior or during coil (single dose 325mg ASA is OK).
  • Have a body weight < 50 or > 150kg.
  • Have historical mRS ≥ 2.

This is a partial list of inclusion and exclusion criteria.

Clinical Trial Area: 
Stroke and Cerebrovascular Disease
Contact Phone: 
(312) 942-6731
Contact Name: 
Rebecca Holtz (Study Coordinator)