|CERNER / EPIC MNEMONIC:|
DNA testing in conjunction with B19 specific serology provides the most reliable evidence of a recent infection.
Monday - Sunday
Collect plasma in sterile tube containing EDTA or ACD as anticoagulant. Whole Blood or bone marrow in sterile tubes containing EDTA or ACD as anticoagulant. Collect amniotic fluid and tissue in sterile container. Collect serum in SST
1 mL plasma, sera, amniotic fluid, whole blood or bone marrow
CSF or Synovial fluid
Plasma, sera, whole blood, bone marrow, and amniotic fluid store and transport refrigerated. Store and ship tissue frozen.
Real-Time Polymerase Chain Reaction (RT-PCR)
Quest, Focus Diagnostics
Parvovirus B19 infection causes "Fifth Disease," a rash illness of childhood characterized by a bright red "slapped cheek" rash and a lacy rash on the trunk and limbs. Joint pain and swelling is more common in adults. Individuals with chronic hemolytic anemia such as sickle cell anemia may develop transient aplastic crisis with severe anemia. Immunocompromised individuals may develop chronic or recurrent bone marrow suppression. Infection during pregnancy can lead to fetal hydrops and spontaneous abortion.