Histoplasma Ab Complement Fixation

CERNER / EPIC MNEMONIC:

HISTOAB CF

CPT CODE:

86698 X 2

CDM NUMBER:

3181443

TEST INFORMATION:

Includes antibody to Yeast Antigen and to Mycelial Antigen

TURNAROUND TIME:

3-7 days

CONTAINER TYPE:

red top Vacutainer tube or SST tube

SPECIMEN REQUIREMENTS:

Serum

REJECTION CRITERIA:

Improper storage of specimen, inappropriate specimen container, insufficient specimen volume

MINIMUM VOLUME:

1 mL

HANDLING INSTRUCTIONS:

Specimen should be transported as soon as possible.  When transportation is delayed, refrigerate.

REFERENCE RANGE:

Yeast Antigen; <8 - Mycelial Antigen; <8

METHODOLOGY:

Complement Fixation (CF)

REFERRAL LABORATORY:

Commercial Laboratory

ADDITIONAL INFORMATION:

Approximately 90 - 95% of patients with histoplasmosis have detectable antibodies.  CF titers>=1:8 are generally considered evidence indicative of histoplasmosis.  Positive titers are also seen with fungal infections other than histoplasmosis, and confirmation of antibody specificity with immunodiffusion procedures is recommended.