Interferon-Beta IgG Antibodies

CERNER / EPIC MNEMONIC:

INTBIGG AB

POE DESCRIPTION:

Interferon Beta IgG Antibodies

CPT CODE:

83520

TURNAROUND TIME:

5-7 working days

SPECIAL INSTRUCTIONS:

Provide name of Interferon-Beta used for treatment.

CONTAINER TYPE:

SST tube or Red top tube - 4 mL

COLLECTION:

Collected at least eight hours after interferon injection

SPECIMEN REQUIREMENTS:

4 mL blood (1.5 mL serum)

MINIMUM VOLUME:

1 mL blood (0.5 mL serum)

REFERENCE RANGE: See Focus Diagnostics - Search Test Code 20358
METHODOLOGY:

ELISA

ADDITIONAL INFORMATION:

Some multiple sclerosis patients receiving recombinant interferon-beta (IFNb) develop IFNb-specific antibodies that may block the therapeutic effect of the treatment.  This assay screens for IgG antibodies capable of binding to IFNb; all samples with detectable IFNb binding antibodies are then tested for IFNb neutralizing antibodies using a bioassay.  Approximately two weeks are required to perform the neutralization bioassay; those results will be reported separately when available.

TEST SYNONYM(S):Beta Interferon IgG Antibodies