Muscle Biopsy

CPT CODE: 88307
TEST INFORMATION: Test includes routine morphologic diagnosis. Special tests as requested by physician.
DAYS PERFORMED: Mon-Fri, 0800-1400
TURNAROUND TIME: 48 hours to 7 days
SPECIAL INSTRUCTIONS: All biopsies must be scheduled 24 hours in advance with specialty pathologist. Pertinent clinical history and laboratory data must accompany specimens, as well as specific muscle site biopsied. Outside institutions should contact Client Serivce Representative (312-942-7958) for submission and transport protocol.
CONTAINER TYPE: Sterile specimen container

Routine histology, histochemistry, and electron microscopy:  Submit specimen fresh in saline-moistened gauze.  Deliver to Laboratory Receiving Station, Rm 508 Jelke immediately after tissue is removed.

REJECTION CRITERIA: Improper fixation, improper or discrepant labeling, O.R. specimens with invalid "barcode" ID label
MINIMUM VOLUME: 10 mm x 10 mm x 10 mm segment of muscle
HANDLING INSTRUCTIONS: Deliver specimen to the laboratory immediately after removal.

Special studies (histochemistry and/or electron microscopy) are required for most other muscle diseases (mitochondrial, lipid, glycogen myopathies).  In certain diseases, an additional sample for enzyme assay or genetic analysis may be indicated; in this case, additional muscle should be snap frozen in the operating room.  Liquid nitrogen for freezing may be obtained in Rm 508 Jelke.

All muscle biopsies are sent to Dr. R. Wollman at U of C (773-702-6166)