Lyme Disease Antibodies

CERNER / EPIC MNEMONIC: LYME AB
POE DESCRIPTION: LYME DISEASE ANTIBODIES; LYME AB
CPT CODE:

86618 x2

TEST INFORMATION: The test includes testing for IgG and IgM antibodies to Borrelia burgdorferi.
TURNAROUND TIME: 5-7 working days
CONTAINER TYPE:

Red top Vacutainer® tube or SST tube

SPECIMEN REQUIREMENTS:

4 mL blood (2 mL serum)

MINIMUM VOLUME:

2 mL blood (1 mL serum)

REFERENCE RANGE: See Specialty Labs - Search Test Code 8942
ADDITIONAL INFORMATION: Borrelia burgdorferi is the etiologic agent of Lyme disease. Lyme disease is a multisystem disorder, with rash and arthritis conspicuous symptoms. It is widespread in the U.S. and is caused by Borrelia burgdorferi, a spirochete transmitted by the bite of the tick Ixodes dammini. The disease has protean manifestation, can become chronic, and responds to antibiotics, so prompt proper diagnosis is important. False negative results can be seen in patients with early disease (less than 8 weeks) or in patients treated with antibiotics early after onset of erythema migrans (EM). False positive results can be seen with syphilis, lupus, rheumatoid arthritis, and mononucleosis. These diseases should be considered and appropriate serological evaluation pursued, if clinically indicated.The assay is available for total antibody in both serum and cerebrospinal fluid. Most patients with chronic disease will have positive assays.A fourfold or greater rise in titer between acute and convalescent IgG antibodies provides evidence sometimes not attained until 2 months or more after onset of illness. Therefore, a single sera should be collected at least 4 weeks post onset. All serum specimens determined to be positive will undergo Lyme Western Blot confirmatory testing.  See Specialty Labs - Search Test Code 7711B
TEST SYNONYM(S):Lyme Arthritis Serology