Cryoglobulin Detection and Quantitation

CERNER / EPIC MNEMONIC: CRYOGLOB
POE DESCRIPTION: CRYOGLOBULIN
CPT CODE:

82595-90

TEST INFORMATION:

Use this test to determine the presence and quantity of cold insoluble immune complexes in patients with systemic immune complex diseases; determine the presence and quantity of monoclonal cryoglobulins in patients with plasma cell dyscrasias.  If cryoglobulin is present, cryoprecipitate is tested.  Please submit correct volume of blood.

TURNAROUND TIME:

10 working days

SPECIAL INSTRUCTIONS:

Overnight fasting is required. The specimen MUST be kept at body temperature (37°C, 98.6°F) from the time the blood is drawn until delivery to the Core Laboratory. Draw blood into prewarmed tubes, and place tubes in a container of 37°C to 40°C water. Transport to the Core Laboratory, 470 Jelke SC, IMMEDIATELY. Specimen should clot at 37°C.

CONTAINER TYPE:

Three FULL red top Vacutainer (6.0 mL)

COLLECTION:

Specimens accepted Monday through Thursday Only.

SPECIMEN REQUIREMENTS:

18 mL blood (9.0 mL serum).  KEEP BLOOD WARM.

REJECTION CRITERIA:

Specimen not transported on warm water, patient not fasting, specimen hemolyzed, insufficient quantity of specimen, inappropriate specimen container.  Specimen sent Friday through Sunday.

MINIMUM VOLUME:

18 mL blood (9 mL serum)

REFERENCE RANGE:

See Specialty Labs - Search Test Code 1155

LIMITATIONS OF TEST: Small amounts of fibrin may precipitate at both 4 and 37°C and thus may mask trace amounts of cryoglobulin. False-negative or false low cryoglobulin values occur if blood is allowed to clot below body temperature or if the blood is refrigerated prior to processing.
ADDITIONAL INFORMATION: Cryoglobulins are immunoglobulins which precipitate on cooling and redissolve on warming. If cryoglobulin is present, Cryoprecipitate is tested for IgG, IgM, IgA, RF and IFE. Add 2 to 4 days to turnaround time.
LAST UPDATED:

2-10-2014

TEST SYNONYM(S):Cold Precipitins; Cryoglobulins with Reflex to Cryoprecipitate Immunoglobulins