Correlation with clinical findings is imperative since false positive and negative results have been reported. Approximately 10% of the adult population with infectious mononucleosis will not develop heterophile antibodies. Failure to develop heterophile antibodies occurs even more frequently in children. (Refer to Epstein-Barr Viral Capsid Antigen Antibody Titer.) Less than 2% false positives have been reported with Hodgkin`s disease, lymphoma, acute lymphocytic leukemia, infectious hepatitis, pancreatic carcinoma, Cytomegalovirus, Burkitt`s lymphoma, acute lymphocytic leukemia, and rheumatoid arthritis. The simultaneous occurrence of infectious mononucleosis and hepatitis has been reported.
Rapid latex particle agglutination.
The test detects heterophile antibodies related to infectious mononucleosis.