Cryoglobulin Detection and Quantitation (View in report form.)
CERNER / EPIC MNEMONIC:
Use this test to determine the presence and quantity of cold insoluble immune complexes in patients with systemic immune complex diseases; determine the presence and quantity of monoclonal cryoglobulins in patients with plasma cell dyscrasias. If cryoglobulin is present, cryoprecipitate is tested. Please submit correct volume of blood.
10 working days
Overnight fasting is required. The specimen MUST be kept at body temperature (37°C, 98.6°F) from the time the blood is drawn until delivery to the Core Laboratory. Draw blood into prewarmed tubes, and place tubes in a container of 37°C to 40°C water. Transport to the Core Laboratory, 470 Jelke SC, IMMEDIATELY. Specimen should clot at 37°C.
Small amounts of fibrin may precipitate at both 4 and 37°C and thus may mask trace amounts of cryoglobulin. False-negative or false low cryoglobulin values occur if blood is allowed to clot below body temperature or if the blood is refrigerated prior to processing.
Cryoglobulins are immunoglobulins which precipitate on cooling and redissolve on warming. If cryoglobulin is present, Cryoprecipitate is tested for IgG, IgM, IgA, RF and IFE. Add 2 to 4 days to turnaround time.
Cold Precipitins; Cryoglobulins with Reflex to Cryoprecipitate Immunoglobulins