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Rush Medical Laboratories
Indications for Blood Products
Blood Components Available from Blood Center

Component/ Product Composition Approximate
Volume *

Indication/Qualifiers
Red Blood Cell Products
Red blood cells RBC; reduced plasma 330 mL Increase red cell mass
Washed RBC RBC; minimal plasma 250 mL Increase red cell mass; reduce febrile or allergic reactions due to cytokines or plasma proteins
Frozen, thawed, deglycerolized RBC RBC; minimal WBC and platelets; no plasma 180 mL Increase red cell mass; reduce febrile transfusion reactions; reduce sensitization to leukocyte antigens; minimize allergic transfusion reactions; rare or autologous blood storage
Autologous blood Autologous RBC or whole blood 180-500 mL Increase red cell mass with predeposited autologous blood
Platelet Products
Platelets by apheresis Platelets; plasma (>3 x 1011 platelets/unit); few RBC 250 mL Prevention of bleeding due to thrombocytopenia or thrombocytopathy (5-day shelf-life). May be HLA matched, if specified
Pooled platelets - platelet concentrates from 4 units of blood Platelets (average of 9x1010 platelets/unit); plasma; few RBC 200 mL Prevention of bleeding due to thrombocytopenia or thrombocytopathy (shelf life 5 days for unpooled units, 4 hours after pooling).
Plasma Products
Fresh frozen plasma Plasma; all coagulation factors; complement (no cellular components 250 mL Treatment of some coagulation disorders
Pooled cryoprecipitate - from 4 units of blood Fibrinogen; factors VIII and XIII; von Willebrand factor; fibronectin 60 mL Deficiency of factor XIII or fibrinogen; treatment of von Willebrand disease
Rh immune globulin IM IgG anti-D 1 mL Prevention of hemolytic disease of the newborn due to D antigen
WinRho IV IgG anti-D 2.5 mL Treatment of ITP, suppression of Rh immunization
* Note: Smaller aliquots may be prepared for infants/children
Coagulation Factors Available
VIII
Recombinatea
VIII
Hemofil-Mb
Humate-P (vWF)
IX
Benefixa
Activated
Feiba-VH
NovoSevena
a. Recombinant b. Affinity-purified with monoclonal antibody


Special Requirements

1. Leukocyte reduced blood components contain less than 5 x 106 WBC per unit and may reduce febrile transfusion reactions; reduce sensitization to leukocyte antigens.

2. A low risk of CMV in cellular blood components will be achieved by leukocyte reduction unless a CMV seronegative product is specified. CMV low risk cellular blood components are indicated for: certain transplant recipients; intrauterine transfusions; exchange transfusions in neonates. Neonates with birth weight less than 1200g whose mother's CMV status is negative or unknown should receive CMV low risk blood products for the first four months of life.

3. Stem Cell Transplant - Pre-transplant: Potential transplant candidates who are CMV-negative or not yet CMV tested should receive CMV low risk cellular blood components and should be tested as soon as possible. Post-transplant: CMV-negative bone marrow transplant recipients who receive CMV-negative donor stem cells should receive CMV low risk cellular blood components for four months post-transplant.

4. Irradiated blood components are indicated for: stem cell transplant recipients starting two weeks prior to transplant and continuing indefinitely; intrauterine transfusions and any neonatal transfusions following them; pediatric patients with congenital or acquired immunodeficiencies; directed donations from blood relatives. To accomplish the latter, all directed donations and all single donor platelets are routinely irradiated in the Blood Center.

5. HLA matched platelets require prearrangement with the Blood Center (2-5920) and HLA typing and HLA antibody screening by the HLA lab (2-8393).





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