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Clinical Trails at Rush Biomarker Qualification for Risk of Mild Alzheimers Disease and Evaluation of Pioglitazone
Clinical Trial Protocol ID
12011901

Clinical Trial Investigator Name
Raj C. Shah

Clinical Trial Title

Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) due to Alzheimer’s Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone



Clinical Trial Protocol Description
The purpose of this 5-year study is to qualify the biomarker risk algorithm for prognosis of the risk of developing MCI due to AD, and evaluate the efficacy of pioglitazone to delay the onset of MCI due to AD in cognitively normal persons.
 
 
Subjects will receive blinded study treatment taken once daily for study duration. Subjects will undergo cognitive testing and physical examinations, ECGs and blood draws throughout the course of the study. Biannual clinic visits and telephone visits will be conducted. 

At Rush University Medical Center we expect to recruit approximately 100 patients. The treatment will be assigned randomly.



Clinical Trial Eligibility Criteria

 In order to participate you must have:

  • Are 65 – 83 years of age
  • Have a reliable study partner
  • If female, willing and able to take daily vitamin D

(≥ 800 IU) and calcium (≥ 1000mg) supplements, unless medically contraindicated

You will be excluded from the study if  you:
  • Diagnosis of other neurological/psychiatric disease(s), or  serious or unstable illnesses
  • History of drug or alcohol abuse/dependence within past 2 years

This is a partial list of inclusion and exclusion criteria.





Contact Name Lindsay Pluff
Contact Phone 312-563-4111
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Biomarker Qualification for Risk of Mild Alzheimers Disease and Evaluation of Pioglitazone

   
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