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Clinical Trails at Rush Improvement of Motor Symptoms in Parkinson's Disease Study
Clinical Trial Protocol ID
12121112

Clinical Trial Investigator Name
Leo Verhagen

Clinical Trial Title

Open-label study looking at the safety and effect of apomorphine injections (APOKYN) for rapid and reliable improvement of motor symptoms in Parkinson’s disease



Clinical Trial Protocol Description

The purpose of this research study is to learn if APOKYN can rapidly and reliably improve your motor symptoms in the early morning. This study will involve about 100 subjects at approximately 10 centers in the United States and all subjects will receive APOKYN. Up to about 10 subjects are anticipated to be enrolled at Rush University Medical Center. The dose of APOKYN will be gradually increased up to a dose that is best (optimum) for each subject. Once this optimum dose is identified, subjects will receive APOKYN for seven days at the optimum dose. Study participation lasts about 35 days and will include three to five office visits at Rush.



Clinical Trial Eligibility Criteria

You may be eligible to participate in this study if you:

  • Are male or female ≥18 years of age
  • Have a diagnosis of idiopathic Parkinson’s disease
  • Are not currently taking APOKYN and, if previously prescribed APOKYN, did not discontinue therapy due to intolerable side effects/safety reasons
  • Are on levodopa (L-dopa) therapy at a steady maintenance dose, representing an optimal treatment regimen in the opinion of the investigator, for at least four weeks before study participation
  • Are able to adequately differentiate between and describe variations in “on” and “off” states in the opinion of the investigator

You will be excluded from the study if you:

  • Have had changes in your L-dopa dosing regimen four weeks before the screening visit
  • Are female and are pregnant or lactating
  • Participated in any other clinical trial within 14 days of the screening visit

This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. If you wish to inquire via email, please include the title of the study in your message.





Contact Name Luci Blasucci
Contact Phone (312) 563-2900 X 4
Contact E-mail clinical_trials@rush.edu
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