Jochen Reiser, MD, PhD, is chairman of the Department of Internal Medicine at Rush University Medical Center and the Ralph C. Brown, MD, professor of internal medicine at Rush University.
Before joining Rush in 2012, Reiser was the Peggy and Harold Katz Family professor of medicine, anatomy and cell biology at the University of Miami Leonard M. Miller School of Medicine. He also was vice chairman for research in the Department of Medicine, chief of the division of nephrology and hypertension and founding director of the Peggy and Harold Katz Family Drug Discovery Center. He also served as interim chairman of medicine.
Reiser led a team of international researchers and scientists in discovering the first circulating factor known to start the process leading to focal segmental glomerulosclerosis. They found that a soluble form of the urokinase plasminogen activator receptor (suPAR) is a circulating blood factor that can trigger glomerular kidney disease. Because of Reiser’s discovery, the disease is better understood, and researchers can now work toward developing targeted treatments to prevent what suPAR does to the kidney.
Reiser has authored more than 110 medical and scientific articles. He holds more than 10 patents and also serves on the editorial board of a number of leading medical journals. Reiser was recently selected as the editor-in-chief of Frontiers in Medicine/Nephrology, a new type of open access, interactive peer-reviewed journal that is partnering with Nature Publishing Group. Reiser has led international research in molecular mechanisms of glomerular kidney disease. He currently has three NIH-funded grants in renal disease and biomedical research. He is a member of the American Society for Clinical Investigation and was most recently also elected to the American Clinical and Climatological Society.
Reiser earned his medical degree and PhD (summa cum laude) at the Ruprecht Karls University of Heidelberg, Germany, and served his residency in internal medicine at the Albert Einstein College of Medicine in New York. He completed his fellowship in nephrology at Massachusetts General Hospital and Brigham and Women’s Hospital at Harvard Medical School in Boston. Before going to Miami, Reiser was an assistant professor at Harvard Medical School and the founding director of the program in glomerular disease at the Massachusetts General Hospital.
Molecular analysis of proteinuria mechanisms
Cell biology and drug discovery for kidney podocytes
Reiser J, Oh J, Shirato I, Asanuma K, Hug A, Mundel TM, Honey K, Ishidoh K, Kominami E, Kreidberg JA, Tomino Y, and Mundel P. Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha-3 integrin. J Biol Chem. 2004, 279: 34827-34891
Reiser J, von Gersdorff G, Loos M, Oh J, Asanuma K, Giardino L, Rastaldi MP, Calvaresi N, Watanabe H, Schwarz K, Faul C, Kretzler M, Davidson A, Sugimoto H, Kalluri R, Sharpe AH, Kreidberg JA, Mundel P. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest. 2004, 113: 1390-1397
Reiser J, Polu KR, Moller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet 2005; 37:739-44.
Moller CC, Wei C, Altintas MM, Li J, Greka A, Ohse T, Pippin JW, Rastaldi MP, Wawersik S, Schiavi S, Henger A, Kretzler M, Shankland SJ, Reiser J. Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol. 2007;18: 29-36.
Sever S, Altintas M, Nankoe S, Ko D, Wei C, Henderson J, Kretzler M, Cohen M, del Re E, Erickson A, Kerjaschki D, Rudensky A, Nikolic B and Reiser J. Processing of the GTPase dynamin by extralysosomal cathepsin L defines a mechanism for proteinuric kidney disease J Clin Invest. 2007, 117: 2095-2104.
Wei C, Möller CC, Altintas MM, Li J, Schwarz K, Zacchigna S, Xie L, Henger A, Schmid H, Kretzler M, Parrilla R, Bendayan M, Nikolic B, Kalluri R, Carmeliet P, Mundel P, Reiser J. Modification of kidney barrier function by the urokinase receptor. Nat. Med. 2007 Dec 16; [Epub ahead of print].
Altintas MM, Ulgen KO, Palmer-Toy DE, Shih VE, Kompala DS, Reiser J. 2008. Emerging roles for metabolic engineering: Understanding primitive and complex metabolic models and their relevance to healthy and diseased kidney podocytes. Curr Chem Biol 2:68-82
Faul C, Donnelly M, Merscher-Gomez S, Chang YH, Franz S, Delfgaauw J, Chang JM, Choi HY, Campbell KN, Kim K, Reiser J, Mundel P. The actin cytoskeleton of kidney podocytes is a direct target of the anti-proteinuric effect of cyclosporine A. Nat Med. 2008, 14: 931-9388
Moller CC, Flesche J, Reiser J. Sensitizing the slit diaphragm- role of the ion channel TRPC6 J Am Soc Nephrol 2008 Sept 10; [Epub ahead of print].
Möller CC, Mangos S, Drummond I, Reiser J. Expression profiles of TRPC1 and TRPC6 orthologs in zebrafish Gene Expr Patterns. 2008 May;8(5):291-6. Epub 2008 Feb 19.