Safety of URate Elevation in Parkinson Disease: SURE-PD
This study has several purposes. We will look at how safe inosine is in subjects with early PD, and if it causes side effects. We will also see if inosine can raise urate levels in blood (serum) and incerebrospinal fluid (CSF) in subjects with early PD. This information will help us decide whether and how to proceed with a larger study of inosine's ability to slow down the rate of worsening disability in PD.
A total of about 90 men and women with early PD will take part in this study at about 17 sites in the United States. We plan to enroll up to 8 subjects at Rush University Medical Center. Eligible participants will receive study-related evaluations, laboratory tests and the investigational drug at no cost.
You may be eligible to participate in this study if you:
- Have been diagnosed with PD within the last three years
- Are experiencing some of the following symptoms: tremor (shaking), slowness of movement, stiffness, small handwriting, poor balance or problems walking
- Not currently taking medication for your Parkinson's disease symptoms
You will be excluded from this study if you:
- Have atypical parkinsonism
- Have a history of gout or kidney stones
- Have had brain surgery of Parkinson's disease
This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. If you wish to inquire via e-mail, please include the title of the study in your message.