Widely Used Cholesterol-Lowering Drug May Prevent Progression of Parkinson’s Disease

Simvastatin, a commonly used, cholesterol-lowering drug, may prevent Parkinson's disease from progressing further.

Neurological researchers at Rush University Medical Center conducted a study examining the use of the FDA-approved medication in mice with Parkinson’s disease and found that the drug successfully reverses the biochemical, cellular and anatomical changes caused by the disease.

"Statins are one of the most widely used cholesterol-lowering drugs throughout the world," said study author Kalipada Pahan, PhD, professor of neurological sciences at Rush. "This may be a safer approach to halt the disease progression in Parkinson's patients."

Pahan and colleagues from Rush published these findings in the October 28 issue of the Journal of Neuroscience.

The authors have shown that the activity of one protein called p21Ras is increased very early in the midbrain of mice with Parkinson’s pathology. Simvastatin enters into the brain and blocks the activity of the p21Ras protein and other associated toxic molecules, and goes on to protect the neurons, normalize neurotransmitter levels, and improves the motor functions in the mice with Parkinson's.

"If we are able to replicate these results in Parkinson's patients in the clinical setting, it would be a remarkable advance in the treatment of this devastating neurodegenerative disease," said Pahan.

More Information at Your Fingertips:
Read the complete news release.
Learn more about the Department of Gastroenterology at Rush.
Learn more about the Coleman Comprehensive Breast Cancer Center at Rush.