Prevention of Relapse and Recurrence of Bipolar Depression

This is a study of the safety, tolerability, and efficacy of a marketed antidepressant with an FDA-approved mood stabilizer during long-term treatment of bipolar depression.

Bipolar depression is a disorder with few treatment options. Until recently, its treatment has typically been based on unvalidated practice guidelines.  We propose that long-term combined therapy with a mood stabilizer and an antidepressant may be superior to a mood stabilizer alone in preventing recurrent symptoms.

At the end of the study, patients have the option of receiving treatment for three months at no charge, during which time they will be assessed monthly.  For subjects who decline the three months of free follow up care, a referral to a psychiatrist will be offered.

You may be eligible to participate in this study if you:

• Are 18 years of age or older
• Have no history of alcohol or drug dependence within 3 months

This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. If you wish to inquire via e-mail, please include the title of the study in your message.