Minimally Invasive Surgery Plus rt-PA for ICH Evacuation (MISTIE)

The purpose of this trial is to determine the safety of using a combination of minimally invasive surgery and clot lysis with rt-PA to remove intracerebral hemorrhage (ICH). The procedure is to use image-based surgery (MRI or CT) to provide catheter access to ICH for the intervention, which is a one-time clot aspiration followed by instillation of rt-PA over 72 hours. We propose to test if this intervention facilitates more rapid and complete recovery of function and decreased mortality from this condition compared to conventional medical management without subjecting the patient to craniotomy.

You may be eligible to participate in this study if you:

• Are 18-80 years of age
• Have GCS < 14 or a NIHSS > 6
• Have a spontaneous supratentorial ICH > 20cc
• Have symptoms less than 12 hours prior to diagnostic CT scan (an unknown time of symptom onset is exclusionary)

You will be excluded from this study if you:

• Have an infratentorial hemorrhage of the midbrain or lower brainstem
• Have a platelet count < 100,000, INR > 1.7, or an elevated PT or APTT
• Have irreversible coagulopathy
• Have clotting disorders

This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. If you wish to inquire via e-mail, please include the title of the study in your message.