A comparison of two methods of insulin administration in patients receiving parenteral nutrition in the intensive care unit

This is a prospective, randomized clinical trial of all patients in the 30-bed Surgical Intensive Care Unit (SICU) who are started on parenteral nutrition. The aim of this study is to determine the best method to achieve blood glucose levels between 80-120 mg/dL in SICU patients receiving parenteral nutrition for nutrition support.

Patients may be eligible to participate in this study if they:

• Are a Surgical Intensive Care Unit (SICU) patient 18 years of age or older on parenteral nutrition who have had two consecutive blood glucose levels greater than 120 mg/dL

Patients will be excluded from this study if they:

• Have a length of stay in the SICU of less than 36 hours
• Have not randomized/consented within 48 hours of admission to SICU
• Are receiving enteral nutrition or a PO diet
• Transfer to the SICU already receiving parenteral nutrition
• Are already participating in another SICU study
• Are receiving peritoneal dialysis (subjects receiving propofol will only be included if the total propofol infused is less than 35% of total calories)

This is a partial list of eligibility requirements. To inquire about eligibility, please call the contact number provided. If you wish to inquire via e-mail, please include the title of the study in your message.