Genetics of recurrent, early-onset depression II

This study is designed to learn more about major depressive disorder, also known as unipolar depression. The project's goal is to identify genes that predispose individuals to develop major depression. We are seeking adults (19 or older) who have had recurrent major depression with a first onset by age 30, who also have a sibling or parent with the disorder.

Participation includes:

• An interview about experiences with the illness and any pertinent family history information
• A blood draw of approximately 45 cc. (3 tubes)

The study is voluntary and requires only one (three- to four-hour) visit. Most participants come to the Rush University Medical Center campus; however, arrangements can be made to do the interview over the phone and mail out a blood kit. The blood, identified only with a coded number, will be used to crate a cell line and will be stored in a repository in New Jersey. DNA taken from that cell line will be used for scientific research now and in the future. Confidentiality is assured and is closely protected by labeling the data and blood with only a coded number. Information that links that coded number to the individual is kept in a secure and locked cabinet at Rush until it is destroyed.

You may be eligible to participate in this study if:

• You have had recurrent major depressive episodes (more than one, or one lasting two or more years), with onset by age 30
• You are at least 19 years old
• You have a parent or sibling who also has recurrent major depression (onset by age 40)
• No one in your immediate family has bipolar I disorder

This is a partial list of eligibility requirements.