About Myelofibrosis

Myelofibrosis is the replacement of bone marrow by fibroblastic cells or fibrous tissue. It is characterized by the development of blood cells in the liver and spleen. The development of blood cells (hematopoiesis) normally occurs in the bone marrow. Myelofibrosis is the primary form of the disorder myeloid metaplasia, which may be associated with leukemia or carcinoma.

There is no specific treatment for primary myelofibrosis. Blood transfusions are given to correct anemia. Recombinant erythropoietin or androgens may stimulate red blood cell production and may be beneficial. Splenectomy (removal of the spleen) may be indicated where enlargement of the spleen causes symptoms related to the organ’s size. Radiation and chemotherapy may also be used.

There is now significant evidence that patients with myelofibrosis can be cured with an allogeneic bone marrow transplant. Unrelated donors can be used if a matched sibling is not available.