This is a multicenter, prospective, observational study of patients with AIDS, funded by the National Eye Institute.  Patients with a diagnosis of AIDS according to the 1993 CDC criteria, with or without ocular complications, will be enrolled.  The objectives of the study are to monitor trends in the incidence of ocular complications of AIDS; to determine the effect of highly active antiretroviral therapy (HAART)-induced changes in immune status on the incidence and course of ocular complications of AIDS; to determine the characteristics of patients that place them at high risk for ocular complications; and to evaluate the effects of treatments for CMV retinitis and other ocular complications on visual function, quality of life and survival.

• Diagnosis of AIDS according to the 1993 CDC diagnostic criteria (with or without clinical symptoms of CMV retinitis or other ocular complications of AIDS)
• At least 13 years of age