Add-on Therapy for Parkinson Disease with Motor Fluctuations: The goal of this research study is to see if the study drug is safe and well tolerated, and can potentially improve the symptoms of Parkinson disease.

Add-on Therapy in Parkinson's Disease Subjects with End of Dose Wearing Off: The purpose of this research study is to test the effect of the study drug compared to placebo on movement during the on and off states as well as other symptoms associated with Parkinson disease.

Advanced PD Study: The ADVANCE-PD study utilizes an investigational long-acting form of a currently marketed oral medication for Parkinson's Disease that may improve Parkinson's symptoms

Antihypertensive Treatment of Cerebral Hemorrhage (ATACH-II): ATACH-II is a phase III, randomized, multicenter, concurrently controlled, parallel arms design clinical trial examining blood pressure reduction for hypertension in acute ICH.

Anxiety and Epilepsy Treatment Study: This study is comparing two FDA-approved medications to treat anxiety in subjects with a partial seizure disorder.

Clot Lysis: Evaluated Accelerated Resolution of Intraventricular Hemorrhage: CLEAR-III is a multicenter, international, double-blind, randomized study comparing the long-term functional outcomes of lysing ventricular blood clots using EVD combined with rt-PA against EVD compared with placebo (saline) for the treatment of severe IVH.

Creatine Safety, Tolerability and Efficacy in Huntington's Disease: The Huntington Study Group (HSG) is conducting a research study using high-dose, pharmaceutical grade creatine-monohydrate in persons 18 years or older who have clinical features of Huntington disease.

Creatine and Parkinson's Study: This is a multicenter, double-blind, study to determine if creatine is more effective than placebo in slowing the clinical decline of Parkinson disease patients with early, treated PD.

Desmoteplase in Subjects With Acute Ischemic Stroke (DIAS-4): DIAS-4 is a multinational, randomized, double-blind, parallel-group, placebo-controlled, phase III study designed to evaluate the efficacy and safety of desmoteplase in subjects with acute ischemic stroke three to nine hours after symptom onset.

Dyskinesia Rating Scale Study: The purpose of this study is to test different scales used to rate dyskinesia (involuntary movements, other than tremor) to see how well each scale works and identify the best scale that can detect changes in dyskinesia in people treated with amantadine or placebo.

Early Parkinson Disease Research Medication Study: The Parkinson Study Group is conducting a study of the research medication isradipine CR in persons who have early Parkinson disease.

Early Parkinson's Study: The Parkinson Study Group and investigators at Rush University Medical Center are conducting a study of the research medication aplindore in men and women who are at least 30 years of age and have been diagnosed with early Parkinson disease within the last five years.

Early-Stage Parkinson's Disease Study: The sponsor is developing a new drug for the treatment of PD. The purpose of the study is to find out if the study drug works and is safe and well=tolerated in patients with early-stage PD, and to determine how the body deals with the study drug.

Epilepsy Examination Study: Patients who are candidates for epilepsy surgery are asked to donate a small portion of the brain tissue that will be removed as part of their planned, elective surgery. The purpose of the study is to further our understanding of epilepsy and possibly develop new treatments in the future.

Epilepsy Neuronal Changes Study: Patients who are candidates for epilepsy surgery, during which brain tissue will be taken out as part of the standard surgical procedure, are invited to donate a portion of this brain tissue and medical information about themselves so scientists can examines how epilepsy affects the brain.

Epilepsy Phenome/Genome Project(EPGP): Everyone who volunteers for EPGP will be asked to give a sample of their DNA via a blood draw and answer some questions asked by a study nurse or physician.

Epilepsy and Depression (Interictal Dysphoric Disorder): Study to evaluate the safety and efficacy of medication in the treatment of a form of depression in epilepsy known as interictal dysphoric disorder with or without postictal depressive symptoms.

Epilepsy and Mood: The purpose of this research study is to determine if a particular antiepileptic medication may have these same positive results as some of the other antiepileptic drugs have produced on mood.

Extended Release Treatment for Levodopa-Induced Dyskinesia in Parkinsons Disease: This study will evaluate the safety, effectiveness and tolerability of three dose levels of an extended-release treatment of levodopa-induced dyskineisa.

Fragile X Study: Premutation Carriers: Researchers are investigating neurological symptoms in male and female carriers of the FXS premutation, and comparing these symptoms to other carriers and noncarriers of the same age.

Glyburide Advantage in Malignant Edema and Stroke Pilot (GAMES-PILOT): GAMES-PILOT is a multicenter, prospective, open-label, phase IIa trial of RP-1127 (Glyburide for injection) in 10 patients with a severe anterior circulation ischemic stroke who are likely to experience clinically significant brain swelling.

Huntington's Disease Study: This study is looking at the effects of coenzyme Q10 on the progression of functional decline in Huntington's disease, as well as the long-term safety and tolerability of the study dosage.

Insulin Resistance Intervention After Stroke Trial (IRIS): The purpose of IRIS is to determine the effectiveness of pioglitazone, compared with placebo, for prevention of recurrent stroke and heart attack among non-diabetic men and women with a recent ischemic stroke or transient ischemic attack and insulin resistance.

Intracerebral Hemorrhage Study: The purpose of this trial is to determine the safety of using a combination of minimally invasive surgery and clot lysis with rt-PA to remove intracerebral hemorrhage.

Levodopa-Induced Dyskinesia (LID) in Parkinson's Disease: Safety, Tolerability and Efficacy study for the treatment of Levodopa-Induced Dyskinesia (LID) in Parkinson's Disease

Moyamoya Disease Study: Moyamoya disease is a destructive disease of the blood vessels, specifically of the large arteries at the base of the brain. This study involves measurement of brain blood flow and oxygen use with a PET scanner, and clinical follow-up over years.

P-15 Bone Putty Study: The purpose of this study is to evaluate an investigational device used to promote bone growth in cervical fusions.

Parkinson Disease Gene Therapy Study: This study involves gene transfer, an experimental procedure sometimes called gene therapy. In this study, a neurosurgeon administers the experimental drug (CERE-120) directly into brain cells affected by Parkinson disease.

Parkinson's Disease Cognitive Impairment Study: We are currently studying thinking and memory (cognition) in Parkinson disease. We are recruiting participants with PD, some who have cognitive problems and others who do not. The study involves a clinical evaluation and a scan of your brain with magnetic resonance imaging.

Parkinson's Disease Eye Safety Study: A two-year, open label, randomized, parallel group, blinded assessment ophthalmologic safety study of pramipexole ir versus ropinirole in early Parkinson's disease patients

Parkinson's Disease Genetics Study: This study aims to identify the genetic factors that contribute to the development of early-onset Parkinson disease, and to understand how these genetic factors interact with other genes and the environment.

Parkinson's Disease Investigational Drug Study: Researchers want to find out if an investigational drug can help people with Parkinson disease. The study drug is being tested to see if it is safe and tolerable, and to see if it relieves the symptoms of Parkinson disease.

Parkinson's Disease and Sleep Disturbance Study: This is a single-center study of the treatment of hallucinations and sleep disturbances in Parkinson disease patients.

Pax Genes in Adult Primary Brain Tumor Study: Patients who are candidates for brain surgery during which brain tumor tissue will be taken out as part of the standard surgical procedure are invited to donate a portion of this tissue and medical information about themselves in order to allow physicians to study brain tumors.

Pharmacokinetics and Pharmacodynamics of Treatment Drugs for Parkinson's Disease: Researchers want to find out if an investigational drug can help people with Parkinsons disease.

Randomized Multicenter Clinical Trial of Unruptured Brain AVMs (ARUBA): The ARUBA study is a clinical trial to find out better ways of caring for people who have been discovered to have an arteriovenous malformation in the brain that has never bled.

Risk Factors for Women with Cerebral Aneurysm Study: Our study will focus on better understanding why women appear to be at higher risk for the development of cerebral aneurysms.

SURE-PD Study: This study has several purposes. We will look at how safe inosine is in subjects with early Parkinson disease and if it causes side effects. We will also see if inosine can raise urate levels in blood (serum) and incerebrospinal fluid in subjects with early PD.

Spontaneous Intracerebral Hemorrhaging and Diffusion Weighted Imaging: AHADWIICH is a prospective, blinded phase I clinical study funded by the American Heart Association that examines patients with spontaneous ICH in order to determine the presence and effect of DWI lesions on patient outcomes.

Study of Dural Sealant Used in Cranial Procedures: The purpose of this study is to evaluate whether or not an investigational dural sealant can be used safely and effectively to help seal the dura mater after cranial (brain) surgery.

The Use of Intraoperative Image-Guided Navigation During Vertebral Kyphoplasty: Study of the reduction in radiation exposures to patient and surgeon during vertebral kyphoplasty by the use of intraoperative image-guided navigation

Treating Anxiety in Subjects With Epilepsy: A comparison of two FDA-approved medications to treat anxiety in subjects with epilepsy

Treatment of Multiple System Atrophy with Oral Medication: A study investigating the effect, safety and tolerability of an oral medication for the treatment of multiple system atrophy

Treatment of Postural and Gait Dysfunction in Parkinson's Disease: Varenicline (Chantix) for the treatment of postural and gait dysfunction in Parkinson's Disease

Using Computer Software to Study Alzheimer's Disease: Study to evaluate the ability of a novel software program to diagnose and track the progression of Alzheimer's disease using MEG/EEG

Vibration Study: The purpose of this study is to test a 19th-century observation that vibration treatment improves Parkinson disease. The study will also evaluate and compare improvements in Parkinson disease with music therapy alone or with combined music/vibration therapy.