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Severe Liver Disease and Accompanying Hepatic Encephalopathy

Clinical Trial Title: 
Study Testing the Safety and Effectiveness of an FDA-Approved Drug, Rifaximin, in Patients With severe Liver Disease and Accompanying Hepatic Encephalopathy
Clinical Trial Protocol ID: 
12081501
Clinical Trial Investigator Name: 
Nikunj Shah, MD
Clinical Trial Protocol Description: 

The purpose of this study is to investigate the use of rifaximin compared to placebo in subjects with severe liver disease who also have a history of hepatic encephalopathy (HE). Approximately 100 subjects are expected to take part in this research study. Locally at Rush University Medical Center, there are expected to be five subjects enrolled.

Clinical Trial Eligibility Criteria: 

You may be eligible to participate in this study if you:

  • Are male or a non-pregnant, non-breast feeding female 18 years of age or older
  • Have had one or more episodes of overt HE associated with liver disease within the last six months
  • Have a MELD score of 19 or higher

You will be excluded from this study if you:

  • Have consumed an alcoholic beverage within 14 days of the first research or show current evidence of drug dependence
  • Have been diagnosed with HIV as determined by medical history
  • Have renal insufficiency requiring routine dialysis

This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. 

Clinical Trial Area: 
Liver, Biliary and Pancreatic Disorders
Contact Phone: 
(312) 563-3919
Contact Name: 
Diana Giczewski